Endocrine Abstracts

Non-alcoholic fatty liver disease (NAFLD) is becoming more common over the world. Its predisposition for evolving to cirrhosis and hepatocellular cancer, as well as its link to extrahepatic symptoms, puts patients and clinicians under a double burden. Several studies have found a link between NAFLD and many endocrinopathies, demonstrating a substantial bi-directional link between NAFLD and hypogonadism, in both men and women. In man with T2DM, NAFLD is linked to reduced total ...

Several reports of Graves’ disease (GD) onset after COVID-19 vaccination were recently published. The mechanism underlying GD occurrence in these cases could be related to the autoimmune syndrome induced by adjuvants (ASIA), a condition triggered by several vaccine adjuvants and excipients leading to dysfunctional immune response causing different conditions and endocrinopathies in genetically predisposed subjects. In Italy, population campaign for COVID-19 vaccination st...

Background: Hyponatraemia is a common electrolyte abnormality that is associated with significant morbidity and mortality in patients admitted to hospital. Fluid restriction is the recommended treatment option for syndrome of inappropriate antidiuretic hormone secretion (SIADH), a common cause of hyponatraemia with limited evidence for alternative treatment options. The aim of our study was to share the experience of our hospital in the successful management of SIADH where we ...

In recent years, US-guided thermal ablation techniques have been proposed as a therapeutic alternative to traditional surgery or to metabolic radiotherapy for thyroid nodes. RFA is one of the most used technique and experience in both ultrasound and ultrasound interventional is important for results and minimizing complications. We present our experience after 1 year of activity on the first 33 patients with thyroid nodules treated with RFA. The nodules were evaluated by ultra...

Recently ultrasound-guide radiofrequency thermal ablation has been proposed as an effective and safe procedure for treating patients who have low risk papillary thyroid microcarcinomas or are unfit for surgery. We present the case of a 56 years old patient with a small (10 mm) thyroid nodule diagnosed as TIR 4, suspect citology for papillary carcinoma after fine needle aspiration. The nodule was also studied with CEUS (Sonovue US contrast medium) which showed increased vascula...

Introduction: Acromegaly is a chronic disease that requires continuous follow-up and examinations over time. During the COVID-19 pandemic outbreak many endocrinological scientific societies recommend to reduce pituitary patient access to hospital facilities to decrease risk of infection. Aim: The aim of our study is to evaluate the impact of restrictions on outpatient access in the clinical management of the patient with acromegaly during COVID19 pandemi...

The hypothalamic-pituitary-adrenal axis is the primary neuroendocrine system activated to establish homeostasis during the stress of critical illness and surgery. However, such critical states also trigger a systemic inflammatory activation that usually precedes the release of adrenocorticotrophic hormone (ACTH) and cortisol. Systemically or locally induced inflammation of the adrenal gland had been described during critical illness. This facilitates...

The hypothalamic-pituitary-adrenal axis is the primary neuroendocrine system activated to establish homeostasis during the stress of critical illness and surgery. However, such critical states also trigger a systemic inflammatory activation that usually precedes the release of adrenocorticotrophic hormone (ACTH) and cortisol. Systemically or locally induced inflammation of the adrenal gland had been described during critical illness. This facilitates...

Objectives: A sporadic association between thyroid and non-organ-specific autoimmunity has been reported, which could be relevant for Graves’ orbitopathy (GO), an autoimmune disease affecting orbital connective tissue. We investigated whether there is an association between GO and anti-nuclear antibodies (ANAs).Methods: We performed a cross-sectional investigation in 265 consecutive patients with Graves’ disease (GD) who came to our observation...

Objective: The treatment with proton pump inhibitors (PPI; omeprazole, pantoprazole, lansoprazole) used for gastritis, gastric ulcer, etc. could lead to L-thyroxine (L-T4) malabsorption issues, that is induced by the increased gastric pH. Many factors like age, way of assumption (during breakfast or with food), other drugs interferences, drug-kinetics, adherence to therapy, could impair the L-T4 absorption.Methods: The study involved 27 hypothyroid patie...